The strategic utilization of specific exogenous compounds, such as hormones, neurotransmitter precursors, vitamins, and minerals, to optimize the complex neurochemical processes that govern sleep initiation, maintenance, and architecture. This approach aims to address underlying biochemical imbalances that disrupt the natural sleep-wake cycle, extending beyond simple sedation. Effective support ensures the restorative qualities of non-REM and REM sleep stages.
Origin
This clinical concept emerges from the intersection of chronobiology, neuroendocrinology, and functional medicine, recognizing sleep disturbance as a systemic issue with profound hormonal and metabolic consequences. The term emphasizes a root-cause resolution strategy, moving past symptomatic treatment to address the foundational chemical requirements for healthy sleep regulation.
Mechanism
Support is typically delivered by modulating the production and signaling of key sleep-regulating neurohormones, notably melatonin and serotonin. Interventions may involve supplementing with essential cofactors for neurotransmitter synthesis, such as magnesium or B vitamins, or directly administering compounds like L-Tryptophan. The primary function is to stabilize the Hypothalamic-Pituitary-Adrenal (HPA) axis, reduce nighttime cortisol spikes, and facilitate the natural, rhythmic transitions between sleep stages, thereby maximizing overnight repair and memory consolidation.
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