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Biochemical Feedback Loop Respect

Meaning

Biochemical Feedback Loop Respect is the guiding clinical principle of administering hormonal or pharmacological interventions in a manner that consciously minimizes suppression or disruption of the body’s natural, finely tuned endocrine axes. This respectful approach acknowledges the critical role of the hypothalamic-pituitary-gonadal (HPG) and hypothalamic-pituitary-adrenal (HPA) axes in maintaining systemic homeostasis and endogenous hormone production. The aim is to support and modulate, rather than replace, native endocrine function, which is paramount for long-term health, fertility, and seamless cessation of therapy if desired.