The clinical strategy of assessing and modulating sequential biochemical reactions within endocrine or metabolic pathways to maintain systemic equilibrium. This involves understanding the interconnected nature of enzymatic reactions and feedback loops that govern physiological function. Effective management aims to prevent pathological amplification or dampening of these processes.
Origin
Draws from systems biology and biochemistry, framing physiological regulation as a series of controlled, interconnected reaction sequences. Management implies an active intervention within these sequences rather than just observing endpoints. It reflects a systems-level approach to physiology.
Mechanism
Operates by modulating key regulatory steps, such as enzyme activity via substrate availability or allosteric effectors, thereby controlling the flux through the cascade. In endocrinology, this might involve managing the rate-limiting steps in steroidogenesis or neurotransmitter synthesis. Precise control over these steps prevents runaway reactions or signal attenuation.
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