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Bioavailable Testosterone Importance

Meaning

This concept emphasizes the critical physiological significance of the fraction of circulating testosterone that is not tightly bound to Sex Hormone-Binding Globulin (SHBG) and is therefore readily accessible to target tissues. Bioavailable testosterone comprises both free testosterone and the portion weakly bound to albumin. It is this active fraction, not total testosterone alone, that primarily dictates androgenic effects, influencing libido, muscle mass, bone density, and neurocognitive function.