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Bioavailable Estrogen Signaling

Meaning

Bioavailable Estrogen Signaling refers to the biological activity initiated by the fraction of estrogen hormones that are unbound to carrier proteins, such as Sex Hormone-Binding Globulin, making them readily available to interact with target cell receptors. It represents the functional component of estrogen that directly influences physiological processes throughout the body. Clinically, assessing this bioavailable fraction provides a more accurate picture of tissue exposure and hormonal impact than measuring total estrogen levels alone. The precise amount of free hormone dictates the magnitude of downstream cellular response and subsequent health outcomes.