What is the Origin of Bioavailability Optimization?

This term is derived from the core tenets of pharmacokinetics, the study of how a substance moves through the body, originating from the Greek pharmakon for drug and kinetikos for motion. The "optimization" element reflects the modern pharmaceutical and nutraceutical science dedicated to overcoming natural biological barriers to absorption.

What is the Mechanism of Bioavailability Optimization?

Optimization strategies focus on circumventing or minimizing pre-systemic elimination factors, such as degradation by gastric acids, poor intestinal permeability, or extensive first-pass metabolism in the liver. Techniques employed include formulating the compound into liposomes, utilizing micro- or nano-particle technologies, or co-administering absorption enhancers to facilitate passive or active transport across the gut epithelium, thereby maximizing the therapeutic exposure.

Bioavailability Optimization

Meaning

Bioavailability Optimization is the strategic enhancement of the degree and rate at which an administered substance is absorbed into the systemic circulation, allowing it to reach its site of action with greater efficiency. This clinical metric is fundamentally important because the therapeutic effect of any compound is directly proportional to its concentration at the target tissue. Improving bioavailability ensures a larger, more predictable fraction of the dosage is physiologically active.