What is the Origin of Bioavailability Metrics?

The concept of bioavailability originates in pharmacology and pharmacokinetics, the study of how the body handles drugs over time. 'Metrics' refers to the quantifiable parameters used, such as Area Under the Curve (AUC) or peak plasma concentration (Cmax), derived from time-concentration curves. Applying these metrics to hormonal health ensures that supplemental or therapeutic agents are efficiently utilized by the body.

What is the Mechanism of Bioavailability Metrics?

The mechanism involves measuring the concentration of the active compound in the plasma or at the site of action over a specific time interval following administration. Factors influencing these metrics include the compound's absorption from the gut, first-pass metabolism in the liver, and the transport mechanisms within the circulation. High bioavailability is achieved when these physiological barriers are effectively bypassed or overcome, leading to a robust and predictable systemic concentration of the therapeutic agent.

Bioavailability Metrics

Meaning

Bioavailability Metrics are quantitative measurements used to assess the fraction of an administered substance, such as a nutrient, hormone, or pharmaceutical compound, that reaches the systemic circulation and is available to exert its biological effect. These metrics are critical in hormonal health to determine the true efficacy of delivery systems and dosing strategies. They move beyond simple dosage to evaluate the effective concentration of a compound at the target tissue level. Optimizing these metrics is essential for achieving desired therapeutic outcomes with precision.