The complex, intricate process by which specific, biologically active chemical compounds initiate a cascade of events within a cell, regulating cellular function, differentiation, and survival. These molecules include hormones, neurotransmitters, cytokines, and growth factors that act as messengers in the body’s communication networks. Understanding this signaling is fundamental to clinical endocrinology and targeted therapeutic development.
Origin
The term draws its roots from molecular biology and pharmacology, emphasizing the specific, non-random nature of chemical communication in biological systems. ‘Bioactive’ denotes a direct effect on living tissue, while ‘Signaling’ refers to the transduction of information from the cell exterior to its interior, often via receptor binding.
Mechanism
The mechanism begins with the binding of a bioactive molecule to its cognate receptor, which can be located on the cell surface or intracellularly. This binding event triggers a second messenger system, such as cyclic AMP or calcium influx, which ultimately modifies gene expression or enzyme activity. Hormonal signaling, for example, precisely dictates physiological responses by modulating the sensitivity and density of these cellular receptors.
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