This term refers to the controlled release of biologically active substances, such as hormones, cytokines, and neuropeptides, from cells or glands into the circulation or interstitial fluid. These molecules exert profound effects on target cells, orchestrating physiological responses throughout the body. The rate and rhythm of this secretion are critical determinants of systemic hormonal balance and metabolic function.
Origin
The concept is fundamental to classical endocrinology, where secretion derives from the Latin secretio (separation, division), describing the process of a substance being produced and discharged. The adjective bioactive emphasizes the molecule’s ability to elicit a specific biological response. In the context of hormonal health, this term specifically addresses the functional output of endocrine tissues.
Mechanism
Secretion is typically initiated by a specific stimulus, triggering a cascade of intracellular events that lead to the exocytosis or diffusion of the molecule. For instance, pituitary cells secrete trophic hormones in response to hypothalamic releasing factors, which then govern peripheral gland secretion. Proper regulation of this process is vital for maintaining homeostatic control and facilitating adaptive changes in response to stress or energy demands.
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