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Bioactive Hormone Ratios

Meaning

The Bioactive Hormone Ratios represent the proportional relationship between the unbound, free fraction of a hormone and its total concentration in the bloodstream. This specific ratio is the most clinically significant indicator, as only the free hormone is capable of diffusing across cell membranes to activate intracellular receptors and elicit a biological effect. Clinicians utilize this precise measurement to determine the true magnitude of hormonal signaling available to target tissues, moving beyond the often misleading total hormone levels. Maintaining an optimal ratio is fundamentally necessary for ensuring balanced endocrine function and supporting systemic physiological health.