The endogenous production or metabolic synthesis of chemical substances within the body that exert specific, measurable effects on physiological processes, cellular function, or organismal health. These compounds, which include hormones, neurotransmitters, and specialized metabolites, are distinct from basic nutrients. Their generation is a fundamental aspect of maintaining systemic homeostasis and adaptive capacity.
Origin
This concept originates from the convergence of biochemistry, pharmacology, and nutritional science, emphasizing the functional output of metabolic pathways. “Bioactive” combines the Greek bios (life) and Latin activus (active), referring to substances that influence living tissue. Generation highlights the process of de novo synthesis or conversion from precursors.
Mechanism
The process is governed by specific enzymatic pathways, often relying on essential nutrient cofactors and substrate availability. In the context of gut health, microbial fermentation of dietary fibers generates short-chain fatty acids (SCFAs), which act as crucial bioactive compounds. Throughout the body, this generation process is tightly regulated by genetic expression and environmental signals to meet the host’s physiological demands.
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