The fidelity and clarity of communication between cells, tissues, and the endocrine system, ensuring that molecular messages are transmitted accurately without degradation or noise. In hormonal health, this means receptor binding affinity and downstream signal transduction pathways function without pathological interference. It is the prerequisite for appropriate physiological response.
Origin
Stemming from biophysics and cellular communication studies, this concept is applied here to the complex milieu of hormone-receptor interactions. Maintaining integrity ensures that feedback loops function as designed by evolutionary biology.
Mechanism
Integrity relies on the correct synthesis, transport, and metabolism of signaling molecules like steroids and peptides, alongside the unimpaired structure of their target receptors. Disruptions, perhaps due to oxidative stress or xenobiotic exposure, lead to signal attenuation or erroneous activation, manifesting as endocrine imbalance.
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