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Bio-Receptor Sensitivity

Meaning

This term describes the functional responsiveness of biological receptors, such as those for hormones or neurotransmitters, to their specific ligands. High sensitivity implies that a low concentration of the signaling molecule elicits a robust downstream cellular response. Conversely, diminished sensitivity, often termed resistance, requires higher ligand concentrations to achieve a comparable effect, reflecting an imbalance in endocrine communication. Understanding this parameter is central to assessing tissue response to endogenous and exogenous signaling agents.