Bio-Identical Hormone Titration is the precise, iterative clinical process of dosing exogenous hormones that are molecularly identical to those naturally produced by the human body. This practice demands careful adjustment to achieve symptom resolution while maintaining serum concentrations within optimal, physiological ranges. We aim for functional equivalence to a healthy endocrine state.
Origin
This strategy is rooted in personalized endocrinology and the practice of pharmaceutical compounding, seeking to move beyond standard, often supraphysiological, synthetic hormone protocols. The term “titration” itself implies careful, step-wise calibration against a desired endpoint.
Mechanism
The mechanism operates by carefully matching the administered dose to the patient’s specific receptor density and metabolic clearance rate for that compound. This process relies on serial laboratory assessment of total, free, and sometimes bound hormone fractions to fine-tune delivery until symptomatic relief and biomarker normalization are achieved simultaneously.
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