These are therapeutic regimens utilizing exogenous hormones that are chemically identical to those naturally synthesized by the human endocrine system, administered for replacement or optimization purposes. The goal is to restore physiological function when endogenous production is insufficient or imbalanced. We aim for molecular congruence with native signaling molecules. This practice is distinct from using synthetic analogues.
Origin
The term arose from the desire to use compounds structurally indistinguishable from endogenous estrogens, progestogens, and androgens, ensuring receptor affinity matches natural substrates. This differentiation highlights a commitment to mimicking natural endocrinology precisely. The origin emphasizes structural identity over chemical modification.
Mechanism
These protocols aim to restore physiological hormone levels by binding to native nuclear receptors in target tissues, such as bone, muscle, and the brain. This binding supports normal cellular signaling, promoting tissue maintenance and function. Precise dosing ensures that receptor saturation occurs without creating supra-physiological stimulation. Proper administration supports systemic homeostasis across multiple axes.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.