What is the Origin of Bio-Identical Hormone Delivery?

The practice evolved from traditional hormone replacement therapy, seeking to minimize potential adverse effects associated with synthetic or non-human-identical hormones. It is rooted in the pharmacological principle that a molecule identical to the endogenous ligand will interact with hormone receptors with maximum biological fidelity.

What is the Mechanism of Bio-Identical Hormone Delivery?

Delivery systems, such as transdermal creams, subcutaneous pellets, or specific oral formulations, are chosen to achieve stable, physiological serum concentrations and avoid non-native metabolic pathways. The goal is to ensure the hormone binds to its cognate nuclear or membrane receptors, initiating the appropriate gene transcription and cellular responses without unintended cross-reactivity or metabolite generation. Precise delivery is key to maintaining endocrine homeostasis.

Bio-Identical Hormone Delivery

Meaning

This refers to the method by which hormones that are chemically and structurally identical to those naturally produced by the human body are administered to a patient. The term encompasses the specific route, dosage form, and schedule used to introduce these hormones into the circulation. This approach aims to replicate the body’s native hormonal signaling as closely as possible.