Interventions aimed at modulating biological processes underlying senescence to extend healthspan. This involves targeted application of physiological and molecular strategies. We seek to optimize cellular function and mitigate age-related decline in endocrine axes.
Origin
Derives from the concept of ‘hacking’ complex systems, applied here to the human biological architecture. Specifically, it references deliberate manipulation of intrinsic regulatory pathways governing longevity. The term integrates systems biology with proactive health management principles.
Mechanism
Optimization often targets epigenetic modifications, mitochondrial efficiency, or the balance of anabolic and catabolic signaling cascades. Modulating factors like NAD+ precursors or senolytic clearance influences cellular senescence burden. Such interventions aim to recalibrate hormonal milieu toward a more youthful physiological state.
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