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Bio-Availability of Androgens

Meaning

Bio-Availability of Androgens is a critical endocrinological metric defining the fraction of administered or endogenously produced androgen hormones, such as testosterone and dihydrotestosterone (DHT), that is accessible to target tissues to elicit a biological effect. This measure is clinically distinct from total hormone levels because it accounts for the portion that is unbound or loosely bound to transport proteins like Sex Hormone-Binding Globulin (SHBG). Only the bioavailable fraction can readily diffuse into cells and interact with androgen receptors.