What is the Origin of BHB Signaling?

The concept originates from the long-standing understanding of ketogenesis, the metabolic process where the liver produces ketone bodies, including BHB, from fatty acids. Recent endocrinology research expanded this view, revealing BHB's role as an endogenous ligand and a histone deacetylase (HDAC) inhibitor. This discovery elevated BHB from a simple energy substrate to a powerful, multifaceted endocrine-like signaling molecule.

What is the Mechanism of BHB Signaling?

The signaling mechanism is multifaceted, involving both direct and indirect cellular interactions. BHB directly binds to G-protein coupled receptors, such as GPR109A, mediating anti-lipolytic effects and systemic communication. Furthermore, its function as an epigenetic modulator involves inhibiting HDACs, which subsequently alters the transcription of genes related to oxidative stress resistance, inflammation, and longevity pathways like Sirtuin 1 (SIRT1). This complex regulatory action helps coordinate the body's response to shifts in nutrient availability.

BHB Signaling ∞ Area

BHB Signaling

Meaning

BHB Signaling refers to the intricate communication pathways initiated by the ketone body Beta-Hydroxybutyrate (BHB) within the body, acting beyond its role as an alternative fuel source. This molecule functions as a signaling messenger, influencing gene expression, epigenetic modifications, and the activity of specific receptors. It represents a key metabolic adaptation that occurs primarily during periods of carbohydrate restriction or fasting, directly impacting systemic energy regulation and cellular homeostasis.