A conceptual framework and integrated set of interventions aimed at optimizing cellular function to surpass typical age-related decline, focusing on epigenetic and metabolic renewal. This approach seeks to restore youthful cellular processes rather than merely slowing senescence. It represents a clinical paradigm shift toward functional longevity and deep biological repair.
Origin
This term is a contemporary synthesis arising from advancements in gerontology, molecular biology, and regenerative medicine, particularly in the study of telomere maintenance and mitochondrial health. The foundation rests upon the scientific understanding of cellular epigenetics and the plasticity of biological aging. It signifies a move beyond chronological age toward biological age optimization.
Mechanism
Recalibration protocols often involve targeted nutritional compounds, specific lifestyle modifications, and potentially advanced therapies to influence gene expression and cellular signaling pathways. The primary mechanisms include enhancing mitochondrial biogenesis, promoting autophagy for cellular cleanup, and stabilizing genomic integrity. This concerted effort improves energy production and systemic hormonal responsiveness.
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