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Beta-Sheet Formation

Meaning

Beta-sheet formation describes a fundamental element of the secondary structure of proteins, characterized by polypeptide chains arranged side-by-side, forming a pleated, sheet-like configuration. This structure is stabilized by inter-strand hydrogen bonds connecting the backbone amide and carbonyl groups of adjacent strands. While crucial for the correct folding and function of many physiological proteins, aberrant beta-sheet formation is clinically significant, as it is a hallmark of protein misfolding diseases. This pathological aggregation can lead to the formation of insoluble amyloid fibrils, which are central to various endocrine and neurodegenerative disorders.