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Beta-Glucuronidase Enzyme

Meaning

Beta-glucuronidase (β-glucuronidase) is a lysosomal enzyme present in various human tissues and, notably, produced by certain bacteria within the gut microbiome. Its clinical significance in hormonal health stems from its role in deconjugation, essentially undoing the body’s detoxification work. High levels of this enzyme are associated with the cleavage of glucuronide conjugates, which include metabolized hormones and toxins, thereby allowing them to be reabsorbed into circulation instead of being excreted. This recirculation can lead to elevated systemic hormone levels, particularly estrogens, which may contribute to conditions like estrogen dominance.