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Beta-Arrestins

Meaning

Beta-Arrestins are a class of intracellular proteins crucial for regulating the signaling and trafficking of G protein-coupled receptors (GPCRs), which includes many receptors for hormones and neurotransmitters. These proteins function primarily to desensitize receptors, preventing excessive or prolonged cellular response to hormonal stimulation. Their role extends beyond simple termination of signaling, as they can also initiate G protein-independent signaling pathways, adding another layer of complexity to cellular communication. Understanding their activity is key to modulating therapeutic responses in endocrinology.