A conceptual process describing the efficient clearance or reduction of accumulated beta-amyloid plaques from the central nervous system, often hypothesized to be influenced by systemic health factors like robust sleep or metabolic state.
Origin
This term blends ‘beta-amyloid,’ the peptide associated with neuropathology, with ‘flushing,’ suggesting a forceful removal mechanism akin to a system purge. It is often discussed in contexts exploring neurodegenerative disease prevention through physiological optimization.
Mechanism
While the precise pathway is still under intensive investigation, the mechanism likely involves enhancing the glymphatic system’s efficiency during deep, slow-wave sleep. Optimal cerebrospinal fluid dynamics, potentially supported by balanced endocrine signaling, are crucial for this waste product removal. A reduction in inflammatory cytokines may also facilitate the breakdown and transport of these protein aggregates.
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