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Beta-Amyloid Accumulation

Meaning

Beta-amyloid accumulation refers to the pathological process where the amyloid-beta peptide, a fragment of the amyloid precursor protein, aggregates into insoluble plaques within the brain parenchyma. This accumulation is a hallmark feature of neurodegenerative decline, particularly Alzheimer’s disease. The presence of these extracellular deposits disrupts synaptic communication and triggers a cascade of neuroinflammatory and oxidative stress responses. Understanding this process is crucial for investigating the neurological aspects of aging and longevity.