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Benefit-Risk Framework

Meaning

This structured approach in clinical practice systematically weighs the potential positive health outcomes, or benefits, against the possible negative consequences, or risks, associated with a therapeutic intervention, such as hormone replacement therapy. It is a critical, patient-centric assessment tool used to ensure that the anticipated physiological improvements, like enhanced bone density or mood stabilization, justify the potential adverse effects, including cardiovascular or thrombotic events. Clinicians use this formal evaluation to guide informed decision-making and personalize treatment protocols for optimal hormonal balance and long-term wellness.