What is the Origin of BDNF Synthesis?

The term BDNF was coined following its discovery in the 1980s, identifying it as a protein factor derived from the brain that nourishes neurons. 'Synthesis' comes from the Greek synthesis, meaning a putting together. The concept of regulating its synthesis is central to modern neuroscience and the clinical pursuit of neuroprotection and cognitive enhancement. It links directly to the plasticity of the brain and its capacity for structural change.

What is the Mechanism of BDNF Synthesis?

BDNF synthesis is primarily governed by gene expression, where the BDNF gene is transcribed into mRNA and subsequently translated into the pro-BDNF protein. This precursor protein is then cleaved by specific proteases to yield the mature, biologically active BDNF. Factors such as physical exercise, caloric restriction, and certain dietary compounds can act as epigenetic regulators, increasing the transcription rate of the BDNF gene. The active BDNF protein exerts its effects by binding to the TrkB receptor, initiating intracellular signaling cascades that promote neurogenesis and synaptogenesis.

BDNF Synthesis

Meaning

The biological process of creating Brain-Derived Neurotrophic Factor (BDNF), a crucial protein belonging to the neurotrophin family. BDNF is vital for neuronal survival, differentiation, and the maintenance of synaptic plasticity within the central and peripheral nervous systems. Adequate synthesis supports learning, memory, and cognitive function, while deficiencies are often implicated in various neurodegenerative and mood disorders. This synthesis is a cornerstone of neurobiological health and resilience.

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BDNF Synthesis

Meaning

Origin

Mechanism

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