What is the Origin of BDNF Polymorphism?

The term originates from the full name, Brain-Derived Neurotrophic Factor, a protein first isolated from the pig brain in the 1980s, highlighting its neurobiological importance. 'Polymorphism' is a standard genetic term denoting a variation in the DNA sequence that is common in a population. The BDNF gene is found on human chromosome 11, and its genetic variations are extensively studied in neuropsychiatry.

What is the Mechanism of BDNF Polymorphism?

The Val66Met polymorphism impacts the pro-domain of the BDNF protein, which is essential for proper packaging and activity-dependent release of the mature factor from the neuron. The Met allele is specifically associated with reduced BDNF secretion in the brain, particularly in the hippocampus and prefrontal cortex, areas critical for memory and executive function. This reduced secretory capacity can modulate an individual's resilience to stress, risk for certain mood disorders, and overall neuroplasticity, influencing brain health across the lifespan.

BDNF Polymorphism

Meaning

A BDNF polymorphism refers to a specific genetic variation within the gene that codes for Brain-Derived Neurotrophic Factor (BDNF), a crucial protein for neuronal health and plasticity. The most commonly studied variation is the Val66Met polymorphism, where the amino acid valine (Val) is replaced by methionine (Met) at codon 66. This alteration subtly affects the intracellular trafficking and regulated secretion of the BDNF protein. Such genetic differences are significant because BDNF plays a vital role in synaptic plasticity, mood regulation, and cognitive function.

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Can Genetic Predispositions Influence the Efficacy of Peptide and Lifestyle Interventions for Cognition?

Genetic predispositions profoundly shape the efficacy of peptide and lifestyle interventions, necessitating personalized protocols for optimal cognitive function.

∞ COMT Polymorphism
∞ Genetic Polymorphisms
∞ Synaptic Plasticity