The strategic enhancement of Brain-Derived Neurotrophic Factor levels within the central and peripheral nervous systems. Elevated BDNF supports neuronal plasticity, survival, and differentiation. In the context of wellness, this is critical for cognitive resilience and mood regulation, often intertwined with metabolic health.
Origin
This concept originates from molecular neuroscience, where BDNF’s role as a neurotrophin was established. Optimization implies applying clinical or lifestyle levers to maximize this factor’s expression. It connects neurobiology directly to observable physiological outcomes.
Mechanism
Optimization frequently targets upstream regulators like exercise, caloric restriction, or specific nutrient signaling pathways that modulate BDNF gene transcription and protein synthesis. Increased activity can upregulate TrkB receptor signaling cascades within neurons. This ultimately reinforces synaptic function and improves overall neural circuit integrity.
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