What is the Origin of Barrier Function?

The concept is fundamental to physiology and immunology, stemming from the recognition of these structures as the primary interface between the organism and its environment. In hormonal health, its significance has grown as the gut-brain-skin axis and systemic inflammation are increasingly linked to endocrine dysregulation.

What is the Mechanism of Barrier Function?

The mechanism involves tight junctions and adherens junctions between cells, supported by a robust extracellular matrix and a specialized mucosal or epidermal layer. Hormones, such as cortisol and sex steroids, directly influence the expression of tight junction proteins and the composition of the barrier. A compromised barrier allows inflammatory mediators to enter systemic circulation, which can then disrupt delicate endocrine feedback loops.

Barrier Function

Meaning

Barrier function refers to the integrity and selective permeability of epithelial and endothelial layers throughout the body, most notably in the skin, gut, and blood-brain barrier. These physical and biochemical defenses are crucial for separating the internal physiological environment from the external or luminal environment. Optimal function is essential for preventing the translocation of toxins, pathogens, and unwanted antigens.