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B-Cell Activating Factor

Meaning

B-Cell Activating Factor, commonly abbreviated as BAFF, is a crucial cytokine belonging to the tumor necrosis factor (TNF) superfamily, playing a pivotal role in the proliferation, differentiation, and survival of B lymphocytes. This factor is essential for maintaining the peripheral B-cell pool and facilitating humoral immunity, which involves the production of antibodies. Dysregulation of BAFF signaling is frequently implicated in the pathogenesis of various autoimmune diseases, where excessive B-cell activity contributes to chronic inflammation and tissue damage.