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Axonal Integrity Maintenance

Meaning

The physiological processes and clinical strategies aimed at preserving the structural soundness and functional capacity of neuronal axons, the primary conduits for electrical and chemical signaling in the nervous system. Maintaining this integrity is paramount for sustained cognitive function, efficient motor control, and proper neuroendocrine communication. Axonal degradation is a key pathological feature in neurodegenerative aging, directly correlating with functional decline. Optimal hormonal balance, particularly neurosteroids, plays a significant role in this protective effort.