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Autophagy-Related Genes

Meaning

Autophagy-Related Genes, frequently denoted as ATG genes, encode the essential proteins required for the cellular process of autophagy, a fundamental catabolic mechanism. Autophagy, meaning “self-eating,” is the cell’s sophisticated, self-cleaning system that degrades and recycles damaged organelles and misfolded proteins. These genes are critical regulators of cellular quality control, directly influencing cell survival, longevity, and metabolic health. Perturbations or polymorphisms within these genetic sequences can significantly impair cellular clearance and contribute to age-related decline and disease pathology.