These are the specific intracellular signaling cascades that initiate the process of macroautophagy, essential for cellular quality control and recycling of damaged organelles.
Origin
Derived from the Greek for ‘self-eating,’ this process is fundamental to cellular homeostasis and survival under nutrient stress.
Mechanism
Induction frequently occurs via the downregulation of the mTOR pathway or the activation of AMPK in response to low energy states, signaling the cell to initiate lysosomal degradation of cellular components.
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