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Autophagic Flux Capacity

Meaning

Autophagic Flux Capacity represents the maximal rate and efficiency at which a cell can complete the process of autophagy, a vital catabolic pathway for cellular self-cleaning. It measures the entire dynamic process, from the formation of the autophagosome to the lysosomal degradation of sequestered cellular components and the subsequent recycling of macromolecules. A robust autophagic flux is a key cellular longevity mechanism, ensuring the clearance of damaged organelles and misfolded proteins, which directly impacts hormonal receptor function and overall endocrine signaling.