This term clinically describes a change in the equilibrium between the sympathetic and parasympathetic branches of the Autonomic Nervous System (ANS). A chronic imbalance, typically favoring sympathetic dominance, indicates a sustained “fight-or-flight” state that is detrimental to restorative physiology. This shift is a key indicator of allostatic load and diminished stress resilience in the body.
Origin
The concept is rooted in human physiology, specifically the Autonomic Nervous System, which derives its name from the Greek auto- (self) and nomos (law), referring to its involuntary control over visceral functions. The term “shift” is a clinical descriptor for a measurable deviation from a healthy homeostatic state.
Mechanism
Sympathetic overactivity, often triggered by chronic psychological or metabolic stress, initiates a cascade that elevates catecholamines and ultimately influences the Hypothalamic-Pituitary-Adrenal (HPA) axis. This sustained neuroendocrine activation diverts resources away from anabolic and reparative processes, such as digestion and immune surveillance. Over time, this imbalance impairs hormonal signaling, contributing to issues like adrenal fatigue and metabolic dysfunction.
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