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Autoimmunity Genetic Load

Meaning

Autoimmunity Genetic Load refers to the cumulative, inherited susceptibility conferred by a collection of specific gene variants, particularly those within the Human Leukocyte Antigen (HLA) complex, that increase an individual’s predisposition to developing autoimmune conditions. This genetic predisposition does not guarantee disease onset but represents a heightened biological vulnerability to immune dysregulation when coupled with environmental triggers. Understanding this load is essential for proactive risk stratification in clinical practice. The degree of load correlates with the probability of immune tolerance breakdown.