What is the Origin of Atrial Fibrillation and Testosterone?

This clinical concept originates from the intersection of endocrinology, specifically androgen physiology, and cardiology, focusing on cardiac rhythm disorders. The study of hormonal influence on cardiovascular risk factors and direct cardiac tissue effects provides the foundational scientific context. Clinical observations in men undergoing testosterone replacement therapy prompted deeper investigation into this specific cardiac risk.

What is the Mechanism of Atrial Fibrillation and Testosterone?

Testosterone may influence AF risk through several physiological pathways, including direct effects on atrial tissue and indirect effects via systemic factors. Androgen receptors are present in the myocardium, suggesting a direct hormonal influence on ion channel function and fibrotic changes within the atria. Furthermore, testosterone therapy can impact hematocrit, blood pressure, and sleep apnea severity, all of which are established risk factors for the onset of atrial fibrillation.

Atrial Fibrillation and Testosterone ∞ Area

Atrial Fibrillation and Testosterone

Meaning

The clinical relationship between the supraventricular tachyarrhythmia known as atrial fibrillation (AF) and the primary male sex hormone, testosterone. This association explores how endogenous or exogenous testosterone levels may influence cardiac electrophysiology and structural remodeling, potentially modulating the risk of developing or exacerbating AF. Maintaining hormonal balance is a critical component of comprehensive cardiovascular health management.