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Astrocytic Metabolic Divergence

Meaning

Astrocytic Metabolic Divergence describes a measurable shift in the primary metabolic pathways utilized by astrocytes, which are crucial glial cells in the central nervous system. Specifically, it refers to a divergence from their typical role in lactate shuttling to neurons toward an altered state, often involving changes in glucose utilization or reliance on alternative substrates. This metabolic change can profoundly impact the nutritional and energetic support provided to adjacent neurons, affecting overall brain function and resilience. Understanding this divergence is key to addressing neuroenergetic imbalances and promoting neurological health.