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Astrocytic Endfeet Function

Meaning

Astrocytic Endfeet Function refers to the specialized role of the terminal processes of astrocytes in maintaining the structural and functional integrity of the blood-brain barrier (BBB) and regulating cerebral microcirculation. These endfeet physically envelop endothelial cells and pericytes, forming a crucial component of the neurovascular unit. Their proper function is vital for regulating the microenvironment necessary for neuronal activity and precise hormonal signaling within the central nervous system. Dysfunction compromises neurological homeostasis.