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Aspartyl Residue

Meaning

The aspartyl residue represents the chemical structure remaining when the amino acid aspartic acid is incorporated into a peptide or protein chain through a peptide bond. This residue carries a negative charge at physiological pH due to its carboxylic acid side chain, making it critically important for protein folding and function. Its presence influences the overall electrostatic properties of hormones and hormone receptors, which is fundamental to their biological activity and binding specificity.