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Asp327Asn

Meaning

Asp327Asn is a standard genetic notation for a specific single nucleotide variation (SNV) or polymorphism where the amino acid Aspartic Acid (Asp) at position 327 in a protein sequence is replaced by Asparagine (Asn). This substitution represents a change from a negatively charged amino acid to an uncharged one, which can significantly alter the protein’s tertiary structure and functional efficacy. Such polymorphisms are frequently studied in genes encoding hormone receptors or metabolic enzymes to predict individual variations in endocrine response. Clinically, understanding this change helps personalize therapeutic strategies.