Question 1

What is the Meaning of Asn680Ser?

Accepted Answer

Asn680Ser is a specific single-nucleotide polymorphism (SNP) found within the gene that encodes the Follicle-Stimulating Hormone Receptor (FSHR), representing a common genetic variation. This polymorphism is characterized by the substitution of the amino acid Asparagine (Asn) with Serine (Ser) at position 680 of the receptor protein. It is a highly studied genetic marker in reproductive endocrinology, particularly concerning ovarian response to gonadotropin therapy.

Question 2

What is the Origin of Asn680Ser?

Accepted Answer

The term is a standardized abbreviation used in molecular biology and genetics, where Asn and Ser denote the respective amino acids, and 680 specifies their location in the protein sequence. The FSHR gene itself is located on chromosome 2, and this particular variant is one of the most frequently investigated polymorphisms in human reproductive medicine. Its clinical significance stems from its impact on the receptor's function in ovarian and testicular tissues.

Question 3

What is the Mechanism of Asn680Ser?

Accepted Answer

This genetic variation is located within the intracellular domain of the FSHR, which is critical for signal transduction after the hormone binds to the receptor. The presence of the Ser/Ser variant, compared to the Asn/Asn variant, often results in a receptor that is less sensitive or responsive to circulating FSH. Consequently, women carrying the Ser/Ser genotype may require higher doses of exogenous FSH during controlled ovarian stimulation protocols in assisted reproductive technology.

Asn680Ser

Meaning

Origin

Mechanism

How Do Individual Genetic Variations Influence Responses to Fertility-Preserving Agents?

How Do Genetic Factors Influence Individual Responses to Fertility Treatments?

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