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Arrestin Proteins

Meaning

Arrestin proteins are a family of crucial regulatory proteins in human physiology that play a primary role in modulating the signaling of G protein-coupled receptors (GPCRs), a vast class of receptors critical for endocrine communication. They function by binding to activated, phosphorylated GPCRs, effectively “arresting” or terminating the receptor’s ability to signal through its primary G protein pathway. This process is essential for preventing overstimulation of target cells by circulating hormones and maintaining cellular responsiveness.