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Aromatase Inhibitor Modulation

Meaning

Aromatase inhibitor modulation refers to the clinical strategy of precisely regulating the dosage and systemic effect of agents that block the aromatase enzyme, the key enzyme converting androgens into estrogens. This targeted intervention is used to manage circulating estradiol concentrations, aiming to reduce estrogenic load and mitigate adverse effects associated with estrogen excess in men and women. Successful modulation requires frequent biochemical monitoring to ensure the optimal balance is achieved, preventing both hyper-estrogenism and excessive estrogen depletion. This is a crucial element in maintaining a healthy androgen-to-estrogen ratio.