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Aromatase Inhibition

Meaning

Aromatase Inhibition is the clinical and physiological process of blocking the enzyme aromatase, a cytochrome P450 enzyme. This enzyme is crucial as it catalyzes the final, rate-limiting step in the biosynthesis of estrogens from androgen precursors, a reaction known as aromatization. Inhibiting this action effectively reduces the systemic and local production of estrogen. This therapeutic strategy is paramount in managing certain hormone-sensitive conditions where estrogen reduction is a key objective. Modulating this enzyme helps maintain the delicate and necessary balance between androgens and estrogens in the body.