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Aromatase Inhibition Cognitive Effects

Meaning

Aromatase Inhibition Cognitive Effects refer to the observed changes in cognitive function, including memory, attention, and executive processing, that can occur following the pharmacological blockade of the aromatase enzyme. Aromatase is responsible for converting androgens into estrogens, and its inhibition significantly lowers circulating estrogen levels in both men and women. The resultant decline in neuroprotective estrogen availability in the brain is hypothesized to precipitate a range of cognitive complaints, often described as a decline in mental sharpness. Clinically, understanding these effects is crucial for managing hormonal therapies.