What is the Origin of Area under Curve?

The concept of the Area under Curve originates from calculus, specifically integral calculus, where it describes the area bounded by a function's graph and the x-axis. It was adopted by the field of pharmacokinetics in the mid-20th century to provide a standardized, quantitative measure of drug exposure from plasma concentration-time graphs. The application of AUC in endocrinology allows for a rigorous, data-driven assessment of endogenous and exogenous hormone profiles.

What is the Mechanism of Area under Curve?

Calculation of the AUC involves plotting the plasma concentration of a hormone against time following administration, then mathematically integrating the area beneath the resulting curve. This integration effectively sums the concentration of the substance in the systemic circulation at every time point measured. The magnitude of the AUC is directly influenced by the drug's absorption rate, its distribution volume, and its elimination rate, providing a composite measure of drug disposition within the physiological system.

Area under Curve ∞ Area

Area under Curve

Meaning

Area under Curve, or AUC, is a fundamental pharmacokinetic parameter representing the total systemic exposure of the body to a drug or hormone over a specified period. Clinically, it quantifies the total amount of active substance that reaches the bloodstream and and is available to exert its biological effect. A higher AUC generally correlates with greater overall drug action, assuming the concentration remains within the therapeutic window. This metric is essential for comparing the bioavailability and efficacy of different formulations or administration routes in hormonal therapy.