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ARA70

Meaning

ARA70, formally known as Androgen Receptor-Associated protein 70, is a nuclear receptor coactivator protein critical for modulating the transcriptional activity of steroid hormones and other nuclear receptors. This protein acts as a crucial molecular bridge within the cell nucleus, amplifying the hormonal signal initiated by ligands like androgens. Its involvement extends beyond androgen signaling to include receptors for thyroid hormone, retinoids, and vitamin D, underscoring its broad regulatory importance in endocrinology. Changes in its expression or function can significantly impact the efficacy of hormone-mediated gene expression.