What is the Origin of AR-V7?

The term AR-V7 originated in the field of oncology and molecular biology, specifically identified and named for its role in conferring resistance to second-generation anti-androgen agents in metastatic castration-resistant prostate cancer (mCRPC). The 'V7' designation refers to the specific alternative splicing event that produces this isoform. Its discovery shifted clinical focus toward understanding non-ligand-dependent AR signaling pathways.

What is the Mechanism of AR-V7?

The functional mechanism of AR-V7 involves its inherent, ligand-independent transcriptional activity. Because the receptor lacks the domain that normally binds hormones and mediates drug-induced inhibition, AR-V7 is continuously localized within the cell nucleus. Once in the nucleus, it binds to androgen response elements on the genome, promoting the expression of genes necessary for cell proliferation and survival, thereby bypassing the inhibitory effects of androgen deprivation and LBD-targeting drugs.

AR-V7 ∞ Area

AR-V7

Meaning

A specific, clinically significant splice variant of the Androgen Receptor (AR) that is generated by the inclusion of a cryptic exon (cryptic exon 3) in the final messenger RNA, resulting in a truncated receptor protein. This particular variant is characterized by the complete absence of the ligand-binding domain, rendering it constitutively active and unresponsive to traditional anti-androgen therapies that target the full-length receptor’s ligand-binding site. Detection of AR-V7 in circulating tumor cells serves as a predictive biomarker for resistance to specific prostate cancer treatments.

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AR-V7

Meaning

Origin

Mechanism

What Advanced Diagnostic Tools Aid Prostate Malignancy Differentiation during Hormonal Therapy?

How Do Androgen Receptors Influence Prostate Response to Testosterone?

Can Personalized Hormone Protocols Mitigate Resistance in Prostate Cancer?

What Are the Clinical Implications of Androgen Receptor Splice Variants in Prostate Cancer?

How Do Androgen Receptor Mutations Affect Prostate Cancer Treatment?

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